does tirzepatide give you headaches Cause and What Can Do about It? How Do You Feel on

Subakir SB, Santosa DIS, Arleni

Jalleh RJ, Plummer MP, Marathe CS, Umapathysivam MM, Quast DR, Rayner CK, Jones KL, Wu T, Horowitz M, Nauck MA (2024) Clinical consequences of delayed gastric emptying with GLP-1 receptor agonists and tirzepatide

SURMOUNT-1 Trial (72-Week Duration, 2,539 Participants): Average weight loss with 15 mg: 20.9% of body weight Participants losing 5%: 91% Participants losing 10%: 82% Participants losing 20%: 57% SURMOUNT-2 Trial (People with Type 2 Diabetes): Average weight loss with 15 mg: 15.7% A1C reduction: 2.0 percentage points Source: Jastreboff AM, et al

These spikes correlate with peak plasma concentration, which occurs approximately 13 days after subcutaneous injection