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Supplementary material The Supplementary Material for this article can be found online at: References Adachi S., Kawamoto T., Otsuka M., Todoroki T., Fukao K

Drug Interactions: Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays

Hormonal Stability Many weight loss approaches disrupt multiple hormonal axes, creating cascading effects on appetite, stress response, thyroid function, and reproductive hormones

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