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Abbreviations TMLD 6- N -trimethyllysine dioxygenase TMABA 4-trimethylaminobutyraldehyde HTMLA -hydroxy-- N -trimethyllysine aldolase SHMT1 & 2 serine hydroxymethyltransferase 1 & 2 TMABA-DH TMABA dehydrogenase -BBH -butyrobetaine hydroxylase OCTN organic cation transporter novel HPRT hypoxanthine phosphoribosyl transferase CD Crohns disease IBD inflammatory bowel disease Footnotes Conflict of interest: All the authors declare having no conflict of interest