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Not only did more than 50% of the participants in a research study lose 15% of their body weight, up to 40% of participants lost up to 20%

Inflammatory cytokines, such as TNF-alpha and IL-6, interfere with insulin signaling and contribute to insulin resistance

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However, the Biden administration in November 2024 proposed to include these agents for their obesity indications in the Part D program, with the goal of improving Americans access to these transformative therapies, according to the CMS fact sheet at the time