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It's important to understand that these medications follow a gradual dose escalation schedule to minimize side effects, particularly nausea and gastrointestinal discomfort

229 A recent study also found that that glucagons ability to induce insulin secretion was reduced in isolated islets from GLP-1R knockout mice, and in wild-type mice a GLP-1R antagonist significantly reduced glucagon-induced insulin secretion

Eating slowly can also make a difference

Whilst transdermal patch formulations represent an area of ongoing pharmaceutical research, no GLP-1 patches are currently licensed by the Medicines and Healthcare products Regulatory Agency (MHRA) or approved by the National Institute for Health and Care Excellence (NICE) for use in the United Kingdom