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Clinically, LOAD begins with episodic memory decline and gradually advances to involve executive dysfunction (Kelly et al., 2020) language disturbances (Paolini Paoletti et al., 2021) and impaired daily living (Guo et al., 2022)

A more complete evaluation may include looking at: food sensitivities and allergy patterns environmental toxin and mold exposure gut microbiome and digestive health chronic infections other inflammatory or immune stressors This matters because mast cell activation is often not a single-trigger problem

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Probiotic Lactobacillus rhamnosus GG promotes mouse gut microbiota diversity and T cell differentiation