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Although meats are rich in dietary protein, it can be a source of mutagens due to the presence of heterocyclic amines (HCA) and polycyclic aromatic hydrocarbons (PAH) during high-temperature grilling and cooking and N-nitroso compounds in processed meats [37]

CDCA-mediated FXR stimulation occurs in ileal enterocytes and hepatocytes and mediates the expression of fibroblast growth factor 15/19 (FGF 15/19) and small heterodimer protein (SHP) (Sonne, 2021)

Finally, there are more invasive treatments like injectables, stents or even surgeries. In Agos case, two doctors recommended surgery

May 16 2023;25(3)doi:10.4088/PCC.22m03344