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No FDA approval: IGF-1 LR3 has never received regulatory approval for human therapeutic use and is restricted to research applications [12]

The pathomorphological description was of a tumor formation with fibrous capsule composed of drained Schwann-like cells with fasciculation, vesicular nuclei with relatively small nucleoli visualized, mitosis 6/10 high-power field (HPF), with varying amount of melanin pigment in single and groups of cells

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Patients with proliferative retinopathy should be referred for treatment according to standards of care established by pivotal studies such as the Diabetic Retinopathy Study, the ETDRS, and the Diabetic Retinopathy Clinical Research Network (DRCR) Protocol S ( Figure 1 )