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In 1922, Charles Kimball and John Murlin identified a pancreatic hormone that elevates blood glucose levels, naming it glucose agonist or simply glucagon. This landmark discovery initiated a century of intensive research and shaped our current understanding of glucagon physiology

Dietary modifications are particularly effective: Reduce gas-producing foods : Temporarily limit beans, lentils, cruciferous vegetables (broccoli, cauliflower, cabbage), onions, and carbonated beverages Eat smaller, more frequent meals : This approach works with Saxenda's mechanism by preventing stomach overload Avoid high-fat foods : Fatty meals delay gastric emptying further, potentially exacerbating symptoms Limit polyols : Sorbitol, mannitol, xylitol and other polyols found in sugar-free products can increase gas production Keep a food diary : Identify personal trigger foods that worsen symptoms Eating behaviour adjustments can significantly reduce air swallowing (aerophagia): Eat slowly and chew food thoroughly Avoid talking whilst eating Don't use straws for drinking Refrain from chewing gum Ensure dentures fit properly if applicable Practical management strategies include: Maintain the prescribed titration schedule : Never increase the dose faster than recommended, as this increases gastrointestinal side effects Stay well hydrated : Adequate fluid intake supports digestive function Regular gentle exercise : Walking after meals can help move gas through the digestive system Consider probiotics : Whilst evidence is limited, some patients report benefit from probiotic supplements, though you should discuss this with your GP or pharmacist first Over-the-counter remedies such as simeticone (activated dimeticone) may provide symptomatic relief for bloating and trapped wind

LaToza, Ph.D

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner