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Furthermore, during a period of inadequate food supply, such as when dieting (especially on ketogenic low-carb diets), the breakdown and oxidation of fats is naturally increased, which explains why people on a diet gradually lose fat

Further, mitochondria of ectopic endometrial stromal cells (ESCs) was found to generate excess ROS (159)

A recent study reported that an engineered biohybrid of DH5 Escherichia coli with hypoxia-inducible lactate oxidase and iron-doped zeolitic imidazolate framework-8 nanoparticles enables targeted lactate depletion, immune activation and ferroptosis, significantly inhibiting tumor growth and metastasis (178)