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How does combining semaglutide therapy with lifestyle modifications such as a balanced diet and physical activity enhance the overall effectiveness of treatment, and what challenges might arise in maintaining these changes
The glucagon receptor component is believed, from early mechanistic studies, to increase energy expenditure and promote fat breakdown (lipolysis), potentially offering metabolic benefits beyond those seen with dual agonists
However, the mechanism of its therapeutic action is not fully understood
Options for prandial glucose management in type 2 diabetes patients using basal insulin: addition of a short-acting GLP-1 analogue versus progression to basal-bolus therapy
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