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Efficacy and safety of co-agonism of GIP, GLP-1, and glucagon receptors by retatrutide in type 2 diabetes: a randomised, placebo-controlled, phase 2 trial

Kiselevsky, Y

Vasconcelos et al., 2025)

In murine models, the activation of GLP-1 receptors within the VTA has been shown to attenuate the synaptic strength of the VTA-NAcc pathway,154 although GLP-1 receptor expression in VTA neurons is relatively sparse.155 Rat studies indicate that GLP-1 receptor activation in the VTA can enhance dopaminergic neuronal activity via presynaptic mechanisms.156 Despite preclinical evidence and limited clinical trials, the precise influence of GLP-1 receptor stimulation on the effects of abused drugs and alcohol remains unclear