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And so I looked up the study, and I was like, this is wild because I happen to know some other things about immune function

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Therefore, in the present study, cultured microglia were exposed to OGD/R to mimic ischemia/reperfusion injury in vitro and were used to determine whether Sirt1 could regulate microglial activation and inflammation following OGD/R injury in vitro and whether these effects were mediated via Shh/GLI family zinc finger-1 (Gli-1) signaling

It has been reported that inflammation induced by direct injection of LPS can disrupt BBB and increase vascular permeability, increasing the infiltration of inflammatory mediators, leading to neuroinflammatory response and cognitive dysfunction (61) (Figure 2)