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In spontaneously hypertensive rats (SHRs), the tripeptides Thea-Thea-Pro (TTP) and GABA-GABA-Pro (gAgAP) produced a sharp and rapid reduction in systolic blood pressure (SBP)

Bahmed K, Henry C, Holliday M, Redzic J, Ciobanu M, Zhang F, et al

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However, none of the therapeutic candidates have been successful so far [10-12] , with the major impediment for most being a failure to cross the blood-brain barrier