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Critical unresolved issues include identifying the molecular switches that govern the transition of autophagy from an anti- to a pro-ferroptotic state, elucidating subtype-specific differences in crosstalk mechanisms, and clarifying the molecular basis underlying proteins such as COX7A1 to exhibit opposing functions

92 Endoplasmic reticulum stress treatment mainly improves the symptoms of UC by regulating endoplasmic reticulum function and reducing the abnormal accumulation of intracellular proteins, thereby inhibiting the inflammatory response of cells

Interestingly, although increased GLUD1 expression decreased mammary epithelial cell proliferation, the reverse occurred in colorectal carcinoma cells, where increased GLUD expression caused increased proliferation, migration and invasion (Liu et al, 2015)