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20 Germ-free animal models have played an essential role in elucidating the functions of GM

Diabetes Care 45 (11), 27532786 (2022)

doi: 10.1016/j.jdiacomp.2012.09.010 5 SlyneJSlatteryCMcMorrowTRyanMP

Corticosteroids promote: Insulin resistance : reducing the body's ability to utilise glucose effectively Increased hepatic gluconeogenesis : stimulating the liver to produce more glucose Lipogenesis : promoting fat synthesis and storage Redistribution of body fat : encouraging central adiposity Hyperglycaemia : elevating blood sugar levels, which can progress to steroid-induced diabetes These metabolic disturbances directly counteract the therapeutic goals for managing fatty liver disease