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In addition, CBS protein levels have been reported to be increased following Akt activation, without affecting CBS mRNA expression (Zhu et al., 2022), which suggests that these pathways may also target CBS enzymatic activity in addition to its expression

The results showed that the changes in gene expression were associated with decreased lipid metabolism (mitochondria using lipids less for fuel) and alterations in the genes needed for energy production in the mitochondria

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Hypothesis 4 Body composition Retatrutide's glucagon-receptor activation drives some of its weight loss through increased energy expenditure, which is mechanistically associated with sparing more lean mass than pure-satiety pathways