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The reality: Injectables Still set the efficacy ceiling Strongest outcomes + label support Oral drugs Lower efficacy (~1113%) But expand the market significantly Key insight: This is not one oral category Oral semaglutide requires fasting + waiting Orforglipron taken anytime The winner may be the least inconvenient drug, not the most effective The Hidden Problem: Persistence This is the part almost no one talks about: Only ~24.5% of patients remain on therapy at 12 months ~20% switch therapies within a year After stopping: Weight regain 0.8 kg per month Let that sink in
1997;273:E981-8
Inflammation and schizophrenia: alterations in cytokine levels and perturbation in antioxidative defense systems
In this environment, they undergo fermentation by the gut microbiota, which contributes significantly to energy production and the generation of various bacterial metabolites
