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Looking at the pipelines set out by major manufacturers, The Pharmaceutical Journal highlights some of the most promising and most novel approaches that could be rolled out to patients in the years to come, unpacking how they work and what benefits they could offer

Semaglutide is a once-weekly GLP-1 injection

A popular dual agonist, tirzepatide (Mounjaro), activates both GLP-1R and GIPR, producing synergistic effects on insulin secretion, appetite suppression, and weight reduction (Table 1)

Not all patients experience clinically meaningful improvements in cholesterol, and some may require additional lipid-lowering therapy regardless of weight loss