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Retatrutide is an investigational triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, developed by Eli Lilly for obesity and metabolic conditions

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Fang XZ, Fang SQ, Ye ZQ et al (2021) NRT1.1 dual-affinity nitrate transport/signalling and its roles in plant abiotic stress resistance

In that case, the post-GLP-1 period can lead to a double loss a concomitant reduction in muscle alongside an increase in fat mass, ultimately resulting in a significantly weakened metabolic engine to maintain balance (Evans & Cummings, 2024)