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The misbalance in redox circuitry in our study makes the cellular structure of the kidney more vulnerable to peroxidative damage as most of the renal lipids are composed of long-chain polyunsaturated fatty acids (Thomas et al., 2009)

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Structural Modification The modification involves deletion of the first three N-terminal amino acids (glycine-proline-glutamate) from the 70-amino acid native IGF-1 sequence, creating a 67-amino acid variant with profound implications for receptor binding, bioavailability, and biological activity