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Genedrug, drugdrug, and drugnutrient interactions may involve mutual inhibition or induction of metabolic pathways, leading not only to potential adverse reactions, nullification or exacerbation of therapeutic effects, but in some cases to fatal outcomes, depending also on whether the compound is a prodrug or an active drug (Dorado et al., 2007

Vallee KAJ, Fields JA (2022) Caloric restriction mimetic 2-deoxyglucose reduces inflammatory signaling in human astrocytes: implications for therapeutic strategies targeting neurodegenerative diseases

Ferroptosis is known to reduce the intracellular GSH level, but the dynamics of this process remains unexplored

Researchers are advised to consult all relevant literature for guidelines on the exact courses of therapy