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His work focuses on how microbial ecosystems interact with human physiology, including: Gut barrier function and intestinal permeability Mucus-associated microbiota (Akkermansia-related systems) Oralgut microbiome axis Short-chain fatty acids (SCFAs) and metabolic signaling Circadian rhythmmicrobiome interactions Clinical Research Contributions He has contributed to multiple clinical-stage microbiome programs, supporting bacterial strain discovery, optimization, and formulation design across different therapeutic areas, including: Active Ulcerative Colitis (Inflammatory Bowel Disease) Hyperoxaluria (Oxalate Metabolism Disorder) Microbiome-driven gut health and inflammatory conditions These studies were part of broader clinical development programs evaluating microbiome-based approaches
Concurrent use with insulin or sulphonylureas significantly increases hypoglycaemia risk, requiring careful dose adjustments before starting Wegovy
In patients with metabolic syndrome, even during disease control periods, BCAA levels remain positively correlated with cardiovascular risk (85)
Furthermore, different from the ordered -helical ECL1 in inactive GLP-1R 33 and -hairpin in inactive GCGR 36 that cover the binding pocket and probably block peptide insertion, ECL1 of active GLP-2R, GLP-1R and GCGR simultaneously move outward and stand upwards in line with TM2 and TM3
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