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Importantly, combination of metformin and radiation significantly increased cell death, when compared to irradiated vehicle controls, highlighting the potential role for altered cell death in the metformin-mediated radiosensitisation of these cell lines

Baur JA, Sinclair DA

ROS dysregulation in respiratory system diseases The dysregulation of ROS is a pivotal mechanism underlying the pathogenesis of various respiratory diseases, causing tissue dysfunction through direct biomolecular damage and activation of inflammatory signaling [374]

Genetic knockout of SHP2 has a profound impact but does not recapitulate or provide information about pharmacologic SHP2 inhibition To better understand the role of SHP2 in PDAC metabolism, we generated PTPN11 knockout (KO) cell lines via CRISPR-Cas9 in human cell lines and employed murine cell lines derived from a dual recombinase PDAC model