Antioxidant support : Glutathione is one of the body's most potent antioxidants, helping to neutralize free radicals and protect cells from oxidative damage
3.2 Preclinical studies of ferroptosis in neurodegenerative diseases 3.2.1 Ferroptosis and alzheimers disease AD is a prevalent and progressive neurodegenerative disorder, characterized by the accumulation of extracellular -amyloid (A) plaques and intracellular neurofibrillary tangles formed by hyperphosphorylated Tau protein, accompanied by excessive neuroinflammation, synaptic dysfunction, and neuronal loss, ultimately resulting in impairments in language, judgment, and executive function, and even leading to the loss of independent living ability ( 1-42 stimulation markedly suppressed the activation of the bone morphogenetic protein 6 (BMP6)/SMAD1 signaling pathway in BV2 microglial cells, resulting in the downregulation of SLC7A11, GPX4, FTL1, and FTH1 expression, increased ROS and MDA levels, and decreased GSH and SOD levels
Liposomal glutathione traditionally glutathione is not thought to be systemically bioavailable when taken orally due to its enzymatic breakdown in the intestine
While topical glutathione has a more favourable safety profile than systemic routes, medical advice is recommended during pregnancy and breastfeeding.
