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Stable GLP-1 Analogs as Therapeutic Intervention Diabetes mellitus is a chronic disease in which the body does not either produce enough insulin or use it inadequately, leading to the hallmarked symptom of high glucose level
In addition, as was previously reported, we observed an increase in the expression of SOD2, which is known to be involved in the mitochondrial oxidative stress pathway 14
A notable example is the CUR-PPR interaction: while PPR enhances CURs bioavailability by inhibiting CYP3A4 and P-gpcritical enzymes for CUR metabolismvia competitive binding to their active sites, this inhibition prolongs systemic CUR exposure
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