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Our study offers novel insights as the first project to link biological consequences of weight loss, namely lower leptin and reduced GLP-1, to eating larger amounts of food, which is a core feature of binge eating, said co-author Lindsay Bodell, a professor in the Department of Psychology at Western University in Ontario, Canada

The fact that the lean body mass decreased from four to eight weeks in the Setria and placebo groups suggests bad experimental design (the researchers hypothesized "eating less" and "over-reaching") -- these variables should be better accounted for in a proper study