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It was first isolated and characterized in 1993 by researchers at the University of Zagreb in Croatia, who derived it from a larger protein naturally found in human gastric juice

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If the mother is tense and stressed and unsure about her abilities to breastfeed, oxytocin production is suppressed

However the small amount of corticosteroid present in the preparation, doses should be adjusted according to the evolution of the condition and patients response, especially in situations of physical or emotional stress, surgery or injury