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Acknowledgements We thank Sarah Crittenden, Hannes Bulow, Alicia Melendez, and John Couchman and members of the Pocock Laboratory and for advice and comments on the manuscript

Shauna Levy, medical director of the Tulane Weight Loss Center, said the biggest challenge for people who opt for the pill version will most likely be adherence: The pill must be taken first thing in the morning, on an empty stomach, with no more than 4 ounces of water