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Sturgess NC, Kozlowski RZ, Carrington Ca, Hales CN, Ashford ML

2016;11(2) doi: 10.1371/journal.pone.0149348

Probiotics exhibit the ability to counteract the metabolic endotoxemia and inflammatory response elicited by pathogenic bacteria through mechanisms such as pH modulation within the intestinal cavity, inhibition of bacterial adhesion and translocation, as well as the secretion of antibacterial substances and defensins (Mueller et al., 2015)

Pain signals keep firing in the nervous system for weeks, months, even years. The odd thing about chronic pain, of course, is you do not necessarily remember when it began or what caused it