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A similar clinical trial using an older GLP-1 medication found that, in a cohort of 200 patients, those receiving the drug showed 18% slower cognitive decline and 50% slower shrinkage of the brain over a year

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The treatment also reshaped the gut microbiota, with correlation analyses indicating that specific bacterial genera associated with TMAO levels were also linked to inflammatory factors and barrier function, underscoring NSPTs role in modulating the oral-gut axis to improve systemic health (Huang et al., 2025b)

Diligently follow your treatment for whatever is causing the hyperpigmentation as your dermatologist prescribes