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However, they found that in knock-in mice expressing MOR mutant S375A substitution, proposed by these authors to be the primary site of morphine-induced phosphorylation of MOR responsible for desensitization (Schulz et al., 2004), morphine tolerance was not affected (Grecksch et al., 2011)

For this gene class, we propose that Ubx WT and Ubx N51A dimerize, thereby facilitating the Ubx N51A -RNA association and splicing regulation (Figure 1N)