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Xiong TT, He P, Zhou M, Zhong D, Yang T, He WH, et al

Normal cold sensitivity associated with weight loss during GLP-1 therapy typically presents as: A general feeling of being cooler than before treatment commenced Needing extra layers of clothing or preferring warmer environments Cold hands and feet, particularly in cool weather Symptoms that correlate with the amount of weight lost No other concerning features such as extreme fatigue, confusion, or changes in heart rate These sensations usually stabilise once weight loss plateaus and the body adjusts to its new composition

Biomarkers of oxidative stress, including reduced glutathione (GSH), oxidized glutathione (GSSG) and glutathione redox/antioxidant capacity (GSH/GSSG), were measured

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