Glutamine is vital for fish during stressful conditions due to its role as a primary energy source for rapidly dividing cells, especially in the immune system and gastrointestinal tract [41, 48]
En modelos animales, se reporta una asociacin entre las concentraciones elevadas de TMAO con una mayor fibrosis tubulointersticial y deposicin de colgeno, como resultado de la fosforilacin de Smad3, el cual es un regulador de la va de sealizacin TFG-B/Smad3, la cual es profibrtica, contribuyendo as a la disfuncin renal progresiva 36
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