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An increase in expression of cellular protectant genes occurs at lower doses of H 2 O 2 than required for HR, and takes place in healthy cells adjacent to necrotic, HR-type lesions in infected leaves (Levine et al., 1994

Mielke, M

In activated macrophage cultures, GHK-Cu administration reduces the production of pro-inflammatory cytokines including interleukin-1, tumor necrosis factor-, and interleukin-6 by 40-65% while simultaneously increasing the production of anti-inflammatory mediators such as interleukin-10 and transforming growth factor-

Oral bioavailability is lower due to enzymatic degradation effective oral doses typically require 35 the parenteral equivalent