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However, unlike previous findings, shikonin, icariin, and other drugs induce mitochondrial dysfunction by increasing ROS levels, decreasing mitochondrial membrane potential, and elevating the release of cytochrome C and pro-apoptotic proteins, such as caspase-3 and caspase-9, to induce apoptosis in FLSs to suppress inflammatory response (265, 266)

Shaamash AH, Elsnosy ED, Makhlouf AM, Zakhari MM, Ibrahim OA: HM EL-d: Maternal and fetal serum nitric oxide (NO) concentrations in normal pregnancy, pre-eclampsia and eclampsia

[DOI] [PubMed] [Google Scholar] 69.Zuo J., Jiang Z

Aromatase mRNA expression in individual follicles from polycystic ovaries