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3xTg mice have been widely used to study geroprotective interventions, and CR has clearly beneficial effects on AD pathology and cognition in this model 4

Following the transfer of aminopropyl groups, dcSAM transforms into 5-deoxy-5-methylthioadenosine, which then can undergo a series of steps in the Met salvage pathway to regenerate adenine and Met (Lauinger and Kaiser, 2021)