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10.1007/s11104-013-1593-4 67 GromovaO

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What's Next: Orforglipron (oral GLP-1) completing Phase 3 trials with submissions expected by year-end 2025 CEO Dave Ricks expects FDA approval by March 2026 International launches accelerating in China, Brazil, India, and Mexico The GLP-1 market is projected to exceed $100B+ by the early 2030s, and Lilly is positioned as the category leader

We hypothesised that varying the timing of metformin administration before a standardised nutrient load would affect glucose-lowering, and, in this proof-of-concept study, we evaluate the effects of metformin administered by intraduodenal perfusion at different time intervals (0, 30 or 60 min) before a standardised intraduodenal glucose load on plasma glucose, GLP-1 and insulin levels in metformin-treated participants with type 2 diabetes