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Among them, 323 (32.3%) were already treated with another GLP-1RA before starting one of the three OW GLP1-RAs of interest, whereas 559 (67.7%) were GLP1-RA naive

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Meanwhile, glucagon receptor activation increases energy expenditure and promotes hepatic fat oxidation, with its hyperglycemic effects counterbalanced by the other two pathways

Therefore, Pdx1-Cre;TRp53 R172H ;Rb f/f is a suitable model in preclinical investigations of exendin-4-based probes for the specific detection of insulinoma