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[29] Up to this point, the hexose monophosphate shunt has generated the following, for each molecule of glucose 6-phosphate metabolized: a pool of three pentose 5-phosphates, ribulose 5-phosphate, ribose 5-phosphate, and xylulose 5-phosphate, which coexist at equilibrium

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Although these drugs were initially developed for the treatment of type 2 diabetes, clinical studies have largely demonstrated their beneficial effects in metabolic, renal, and cardiovascular diseases that go beyond glucose control (Minze et al., 2018