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This protein exerts a dual role, as it also accumulates in the nucleus following DNA damage, thereby enhancing the activity of p53 and leading to cell cycle and apoptosis
Serum iron reflects recent iron intake and does not provide a measure of the iron stores For Other features on the blood film appearance that prompt further investigation, see Additional Notes below MCV classification of anaemia The initial classification is based on the mean corpuscular volume (MCV) Red flags (consider admission) Hb 3.5%, often elevated Hb F) HbA2 may not be elevated in the presence of concomitant iron deficiency, therefore give iron treatment (if ferritin low) before ordering test Red cell distribution width (RDW) is often normal Pre-pregnancy carrier testing of partner is important, ensure parents have been tested if likely to have more children Alpha Thalassaemia minor/trait Carrier of alpha thalassaemia Commonly seen in South East Asian, African, Mediterranean, Arabic families Microcytic hypochromic red cells with normal or borderline low Hb Cannot be diagnosed on HPLC or Hb electrophoresis
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