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In renal tubular epithelial cells treated with calcium oxalate (CaOx) to induce kidney stone formation, CHAC1 expression increases alongside a decreased GSH level, reduced GPX4 activity, increased iron and MDA content and elevated ROS and lipid peroxidation

Methods 64 , 207215 (2005)

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Amino acid metabolism and pulmonary fibrosis Arginine plays a key role in pulmonary fibrosis Arginineproline metabolism in pulmonary fibrosis Emerging evidence indicates that the arginineproline metabolic axis is notably upregulated in pulmonary fibrosis, contributing to excessive ECM deposition and disease progression [66,67,68,69,70]