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Evidence (palliation or prevention of bone metastases using denosumab): A placebo-controlled randomized trial (NCT00321620) compared denosumab with zoledronic acid for the prevention of skeletal events (pathological fractures, spinal cord compression, or the need for palliative bone radiation or surgery) in men with hormonal therapy-resistant prostate cancer with at least one bone metastasis.[47] The median time to first on-study skeletal event was 20.7 months in the denosumab group and 17.1 months in the zoledronic acid group (HR, 0.82

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doi: 10.4132/jptm.2023.05.24 2

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