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Each washing step was followed by centrifugation as mentioned above

88,89 At this time, polyethylene glycol is not Food and Drug Administration-approved nor guideline-recommended (AASLD 2014) for the treatment of HE, though it is mentioned as possible alternative therapy pending further study

6 Limitation and future research priorities Despite the promising potential of ferroptosis-targeting therapies, several limitations currently hinder their translation into clinical practice

For instance, small-molecule NPs (ITIC) based on a donoracceptor-donor (D-A-D) structure have exhibited remarkable cytotoxicity against oral cancer cells and effective tumor ablation in vivo (Cai et al