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Individuals with diabetes are at particularly high risk of NAFLD, theorized to be due to excess energy driving insulin resistance seen in diabetes resulting in increased uptake of free fatty acids in the liver

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Table 1 illustrates that the most significant obstacles to progress across these systems have not been a lack of physiological relevance, but unresolved pharmacologic, technological, or conceptual challenges

If a patient depends only on appetite suppression, maintenance may become difficult when appetite changes or medication access changes