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The peptide binds GHRH receptors on anterior pituitary somatotroph cells, activates adenylyl cyclase to increase intracellular cAMP, enhances transcription of the GH gene, and stimulates exocytosis of stored GH from secretory granules

Our team occasionally recommended carnitine for people on valproic acid/Depakote, to help with residual side effects like muscle weakness and constipation

Peer review Peer review information Nature Communications thanks Hongli Mao, and the other, anonymous, reviewer for their contribution to the peer review of this work

Injection protocol and administration Subcutaneous injection is the standard route for KLOW