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Flow cytometry analysis suggested that AP probe-net arrested the cell cycle in the G2/M phase and induced apoptosis of cells

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Most cytotoxics generate excess reactive oxygen species (ROS) either directly (radiolysis of water, redox cycling of platinum) or indirectly by impairing antioxidant enzymes [71, 72]

Correspondingly, we found that the NAC treatment largely increased the number of surviving SGNs in the peroxynitrite + NAC group compared with the peroxynitrite-only group, as well as in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figure 6D)