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NICE guidance does not provide detailed renal-specific dosing recommendations for weight loss medicines

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Dosing increases may be needed to maintain effectiveness Retatrutide Retatrutide is a once-weekly injectable peptide designed to support weight loss by activating three key metabolic pathways in the body: GLP-1: helps control appetite and slow digestion GIP: enhances insulin response and metabolic balance Glucagon receptor: increases energy use and supports fat burning By targeting all three pathways simultaneously, Retatrutide is considered a triple-agonist therapy , offering a more comprehensive approach to weight management