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The American Diabetes Association guidelines emphasize that while semaglutide has a favorable safety profile, appropriate dosing and patient education remain critical to minimize adverse events and optimize therapeutic outcomes

The US-FDA initially approved the drug in 1942 (7)

Berberine may support 1.5-2 kg of weight loss over several months, compared to 12-15 kg with GLP-1 medications

[116], the increased production of superoxide radicals (O 2 ) resulting from T2D hyperglycemia can rapidly react with nitric oxide (NO) to produce peroxynitrite (ONOO ), which can subsequently react with protein (and apolipoprotein) tyrosine residues to form 3-nitro-tyrosine (3-NT)