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This is further supported by studies (147), which identified deficits in nNOS neurons in various enteric neuropathies, including those associated with IBD

Pro-inflammatory cytokines, including TNF-, IL-1, IL-6, IL-7, IL-15, IL-17, IL-18, IL-23, interferon (IFN)-, granulocyte-macrophage colony-stimulating factor (GM-CSF) have been found to govern inflammation in RA occurrence

Key points about elevated B12: Water-soluble vitamin with significant hepatic storage capacity Elevated levels defined as exceeding laboratory upper reference limit Often discovered incidentally during routine blood tests May reflect underlying pathology rather than toxicity Persistent elevation should be confirmed with repeat testing It is important to note that high B12 levels are generally not considered toxic in the same way as fat-soluble vitamins

doi:10.1097/01.aids.0000131354.14408.fb